Takeda and Actos: A History of Not Caring
It is a product history heard over and over in the world of Big Pharma. A large drug company develops a new drug, tests it, gets FDA approval and then promotes and sells it - often knowing in advance that the drug can be dangerous to the very people it is supposed to help.
That is the story of Actos (pioglitazone), a diabetes medication Takeda markets for the treatment of Type 2 diabetes. More than 60 million prescriptions for Actos have been written since the drug was released in 1999. However, like other drug companies in similar situations, Takeda knew of the history of problems with Actos side effects since before it put the drug on the market.
Actos history: Risks were known early on
Before the drug was released, a two-year animal study revealed a higher incidence of tumors in male rats that were given a dose of Actos that would result in a blood concentration of the drug equivalent to that in humans taking the recommended dose.
In 2005, a peer-reviewed study showed an increased risk of bladder cancer among Actos patients. However, the findings were not included in the final report, which focused instead on heart attack and stroke.
Another study, this one focused on liver toxicity and other drug reactions, also showed an increased risk of bladder cancer.
In 2010, the Food and Drug Administration (FDA) announced that it would review the data from a 10-year study being conducted by Kaiser Permanente to analyze the link between Actos and bladder cancer. In addition to demonstrating the increased risk of the user developing the disease, the study showed that those who used the drug for two years or more and those whose dosage increased faced a greater risk. The FDA required Takeda to include information about this risk on the label in 2011.
Despite these studies, Takeda continued to deny that patients who took Actos were at greater risk of developing bladder or other cancers.
After reviewing the history of Actos, our trial attorneys have taken action to bring together the evidence and resources for an Actos lawsuit. We welcome inquiries from Actos victims and their families and are fighting for compensation for Actos victims. Contact us to speak with a knowledgeable California personal injury lawyer.